新型コロナウイルスの起源問題～RaTG13はフェイクか？～3
図3 キクガシラコウモリとセンザンコウのコロナウイルス、および、SARS-CoV-2のSタンパク・アミノ酸配列の比較（S2サブユニット）
0: LYRa11(2011), 1: CoV ZXC21(2015)、2: CoV ZC45(2017)、
3: PCoV GX-P1E(2017)、4: PCoV MP789(2019)、5: RaTG13(2013),
686-720
0: NTDQKSIVAYTMSLGAENSIAYANNSIAIPTNFS
1: STGQKAIVAYTMSLGAENSIAYANNSIAIPTNFS
2: STSQKAIVAYTMSLGAENSIAYANNSIAIPTNFS
3: SVNQRSIIAYTMSLGAENSVAYSNNSIAIPTNFT
4: SVSSQAIIAYTMSLGAENSVAYANNSIAIPTNFT
5: SVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFT
6: SVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFT
721-760
0: ISITTEVMPVSMAKTSVDCTMYICGDSQECSNLLLQYGSF
1: ISVTTEVMPVSMAKTSVDCTMYICGDSIECSNLLLQYGSF
2: ISVTTEVMPVSMAKTSVDCTMYICGDSIECSNLLLQYGSF
3: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
4: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
5: ISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSF
6: ISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSF
761-800
0: CTQLNRALSGIAVEQDKNTQEVFAQVKQIYKTPAIKDFGG
1: CTQLNRALSGIAIEQDKNTQEVFAQVKQIYKTPPIKDFGG
2: CTQLNRALSGIAIEQDKNTQEVFAQVKQIYKTPPIKDFGG
3: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
4: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
5: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
6: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
801-840
0: FNFSQILPDPSKPTKRSFIEDLLFNKVTLADAGFMKQYGE
1: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
2: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
3: FNFLQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
4: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
5: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
6: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
841-880
0: CLGDISARDLICAQKFNGLTVLPPLLTDEMIAAYTAALVS
1: CLGDISARDLICAQKFNGLTVLPPLLTDEMIAAYTAALIS
2: CLGGISARDLICAQKFNGLTVLPPLLTDEMIAAYTAALIS
3: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
4: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
5: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
6: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
881-920
0: GTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
1: GTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
2: GTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
3: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
4: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
5: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
6: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
921-960
0: QKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQAL
1: QKLIANQFNSAIGKIQESLTSTASALGKLQDVVNQNAQAL
2: QKLIANQFNSAIGKIQESLTSTASALGKLQDVVNQNAQAL
3: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
4: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
5: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
6: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
961-1000
0: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
1: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
2: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
3: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
4: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
5: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
6: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
1001-1040
0: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
1: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
2: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
3: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
4: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
5: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
6: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
1041-1080
0: VDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAP
1: VDFCGKGYHLMSFPQSAPHGVVFLHVTYIPSQEKNFTTAP
2: VDFCGKGYHLMSFPQSAPHGVVFLHVTYIPSQEKNFTTAP
3: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
4: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPSQEKNFTTTP
5: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
6: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
1081-1120
0: AICHEGKAYFPREGVFVSNGTSWFITQRNFFSPQLITTDN
1: AICHEGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDN
2: AICHEGKAHFPREGVFVSNGTHWFVTQRNFYEPKIITTDN
3: AICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDN
4: AICHEGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDN
5: AICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDN
6: AICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDN
1121-1160
0: TFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNH
1: TFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNH
2: TFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNH
3: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
4: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
5: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
6: TFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
1161-1200
0: TSPDVDLGDISRINASVVNIQKEIDRLNEVAKNLNESLID
1: TSPDIDLGDISGINASVVNIQKEIDRLNEVARNLNESLID
2: TSPDIDLGDISGINASVVNIQKEIDRLNEVARNLNESLID
3: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
4: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
5: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
6: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
1201-1240
0: LQELGKYEQYIKWPWYVWLGFIAGLIAIVMATILLCCMTS
1: LQELGKYEHYIKWPWYVWLGFIAGLIAIVMVTILLCCMTS
2: LQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTS
3: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
4: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
5: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
6: LQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTS
1241-1274
0: CCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT
1: CCSCLKGCCSCGFCCKFDEDDSEPVLKGVKLHYT
2: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
3: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
4: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
5: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
6: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
新型コロナウイルスの起源問題～RaTG13はフェイクか？～2
図2 センザンコウのコロナウイルス、RaTG13、SARS-CoV-2のSタンパク・アミノ酸配列の比較（S1サブユニット）
1: PCoV GX-P1E(2017), 2: PCoV GX-P2V(2018), 3: PCoV GX-P4L(2017),
4: PCoV GX-P5E(2017), 5: PCoV GX-P5L(2017), 6:PCoV MP789(2019),
7: RaTG13(2013), 8: SARS-CoV-2 WIV02(2019)
1-40
1: -MFVFLFVLPLVSSQCVNLTTRTGIQPGYTNSSTRGVYYP
2: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP
3: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP
4: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP
5: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP
6: MLFFFFLHFALVNSQCVNLTGRAAIQPSFTNSSQRGVYYP
7: -MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSSTRGVYYP
8: -MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYP
41-80
1: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--NYQGGFKKF
2: DKVFRSSILHLTQDLFLPFFSNVTWFNTIHLNYQGGFKKF
3: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--NYQGGFKKF
4: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--TYQGGSKKF
5: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--NYQGGFKKF
6: DTIFRSNTLVLSQGYFLPFYSNVSWYYALTKTN-SAEKRV
7: DKVFRSSVLHLTQDLFLPFFSNVTWFHAIHVSGTNGIKRF
8: DKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRF
81-120
1: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI
2: DNPVLPXNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI
3: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI
4: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI
5: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI
6: DNPVLDFKDGIYFAATEKSNIVRGWIFGTTLDNTSQSLLI
7: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLI
8: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLI
121-160
1: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV
2: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV
3: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV
4: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV
5: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV
6: VNNATNVIIKVCNFQFCYDPYLSGYYH-NNKTWSTREFAV
7: VNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRV
8: VNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRV
161-200
1: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG
2: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG
3: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG
4: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG
5: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG
6: YSSYANCTFEYVSKSFMLDIAGKSGLFDTLREFVFRNVDG
7: YSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDG
8: YSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDG
201-240
1: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ
2: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ
3: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ
4: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ
5: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ
6: YFKIYSKYTPVNVNSNLPIGFSALEPLVEIPAGINITKFR
7: YFKIYSKHTPINLVRDLPPGFSALEPLVDLPIGINITRFQ
8: YFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQ
241-280
1: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY
2: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY
3: TLLALHRSYLTPGNLESGWTTGAAAYYVGYLQQRTFLLSY
4: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY
5: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY
6: TLLTIHRGDPMPN---NGWTVFSAAYYVGYLAPRTFMLNY
7: TLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKY
8: TLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKY
281-320
1: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR
2: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR
3: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR
4: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR
5: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR
6: NENGTITDAVDCALDPLSEAKCTLKSLTVEKGIYQTSNFR
7: NENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFR
8: NENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFR
321-360
1: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS
2: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS
3: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS
4: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS
5: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS
6: VQPTESIVRFPNITNLCPFGEVFNATTFASVYAWNRKRIS
7: VQPTDSIVRFPNITNLCPFGEVFNATTFASVYAWNRKRIS
8: VQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRIS
361-400
1: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS
2: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS
3: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS
4: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS
5: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS
6: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS
7: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS
8: NCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADS
401-440
1: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV
2: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV
3: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV
4: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV
5: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV
6: FVVRGDEVRQIAPGQTGRIADYNYKLPDDFTGCVIAWNSN
7: FVITGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSK
8: FVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSN
441-480
1: KQDALTGGNY--LYRLFRKSKLKPFERDISTEIYQAGSTP
2: KQDALTGGNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP
3: KQDALTGGNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP
4: KQDALTGGNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP
5: KQDALTGDNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP
6: NLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTP
7: HIDAKEGGNFNYLYRLFRKANLKPFERDISTEIYQAGSKP
8: NLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTP
481-520
1: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN
2: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSXELLN
3: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN
4: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN
5: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN
6: CNGVEGFNCYFPLQSYGFHPTNGVGYQPYRVVVLSFELLK
7: CNGQTGLNCYYPLYRYGFYPTDGVGHQPYRVVVLSFELLN
8: CNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLH
521-560
1: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF
2: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF
3: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF
4: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF
5: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF
6: APATVCGPKQSTNLVKNKCVNFNFNGLTGTGVLTESSKKF
7: APATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKF
8: APATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKF
561-600
1: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT
2: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT
3: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT
4: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT
5: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT
6: LPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT
7: LPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT
8: LPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT
601-640
1: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG
2: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG
3: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG
4: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG
5: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG
6: PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
7: PGTNASNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
8: PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG
641-680-693
1: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSL----RSVNQRS
2: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSF----RSVNQRS
3: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSL----RSVNQRS
4: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSF----RSVNQRS
5: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSF----RSVNQRS
6: SNVFQTRAGCLIGAEHVNNTYECDIPIGAGICASYQTQTNS----RSVSSQA
7: SNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS----RSVASQS
8: SNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQS
新型コロナウイルスの起源問題～RaTG13はフェイクか？～1
On the Origin of the Novel Coronavirus: Is the RaTG13 a Fake?
考察テーマ：RaTG13は本当にナカキクガシラコウモリ（Rhinolophus affinis）のコロナウイルスなのか？
私が興味を持っているのは、新興の感染症Covid-19や免疫やワクチンの問題ではなく、病原体そのものであるSARS-CoV-2のほう、とくにその「謎めいた」起源の問題です。 それは、国内外の多くの科学者が強く指摘してきたとおりの自然発生なのか、それとも、にわかに熱い注目を集めている武漢ウイルス研究所（Wuhan Institute of Virology）の実験室なのか。 私は陰謀論には加担しませんが、後者の可能性がきわめて高いと考える者の1人です。
ちなみに、ウイルス学や免疫学の外部にいる一介の好事家です。
職場に迷惑がかかる懸念から、当面、匿名で考察のための情報を発信するつもりです。
まずは、スパイクたんぱく質（Sタンパク）のデータの一部を以下に示します。
キクガシラコウモリのコロナウイルス、センザンコウのコロナウイルス、そしてSARS-CoV-2のＳタンパクの遺伝子は約1270個のアミノ酸によって構成され、S1サブユニットとS2サブユニットに区分されます（SARS-CoV-2の場合、685番目までがS1、686番目からがS2に該当します）。
図1 センザンコウのコロナウイルス、RaTG13、SARS-CoV-2のSタンパク・アミノ酸配列の比較（S2サブユニット）
1～6はセンザンコウのコロナウイルス、7は武漢ウイルス研究所の石正麗研究員らがSARS-CoV-2にもっとも近い遺伝子配列のサンプルとして挙げた、ナカキクガシラコウモリ（Rhinolophus affinis）のコロナウイルス、8は2019年12月に武漢ウイルス研究所で分離されたSARS-CoV-2。カッコ内は当該ウイルスの採取ないし分離がなされた年。
1: PCoV GX-P1E(2017), 2: PCoV GX-P2V(2018), 3: PCoV GX-P4L(2017),
4: PCoV GX-P5E(2017), 5: PCoV GX-P5L(2017), 6: PCoV MP789(2019),
7: Bat CoV RaTG13(2013), 8: SARS-CoV-2 WIV02(2019)
（Source: GenBank）
S2サブユニットのアミノ酸配列
686-720
1: SVNQRSIIAYTMSLGAENSVAYSNNSIAIPTNFT
2: SVNQRSIIAYTMSLGAENSVAYSNNSIAIPTNFT
3: SVNQRSIIAYTMSLGAENSVAYSNNSIAIPTNFT
4: SVNQRSIIAYTMSLGAENSVAYSNNSIAIPTNFT
5: SVNQRSIIAYTMSLGAENSVAYSNNSIAIPTNFT
6: SVSSQAIIAYTMSLGAENSVAYANNSIAIPTNFT （←複数の変異あり）
7: SVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFT （←同上）
8: SVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFT （←同上）
721-760
1: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
2: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
3: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
4: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
5: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
6: ISVTTEILPVSMTKTSVDCTMYICGDSIECSNLLLQYGSF
7: ISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSF （←Tへの変異）
8: ISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSF （←同上）
761-800
1: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
2: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
3: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
4: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
5: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
6: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
7: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
8: CTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGG
801-840
1: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
2: FNFLQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD （←Lへの変異）
3: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
4: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
5: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
6: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
7: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
8: FNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGD
841-880
1: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
2: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
3: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
4: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
5: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
6: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
7: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
8: CLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLA
881-920
1: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
2: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
3: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
4: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
5: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
6: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
7: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
8: GTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYEN
921-960
1: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
2: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
3: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
4: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
5: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
6: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
7: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
8: QKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQAL
961-1000
1: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
2: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
3: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
4: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
5: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
6: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
7: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
8: NTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITG
1001-1040
1: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
2: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
3: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
4: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
5: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
6: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
7: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
8: RLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR
1041-1080
1: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
2: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
3: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
4: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
5: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
6: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPSQEKNFTTTP （←SとTへの変異）
7: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
8: VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAP
1081-1120
1: AICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDN
2: AICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDN
3: AICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDN
4: AICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDN
5: AICHEGKAHFPREGVFVSNGTHWFITQRNFYEPQIITTDN
6: AICHEGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDN （←Vへの変異）
7: AICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDN （←DとVへの変異）
8: AICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDN （←同上）
1121-1160
1: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
2: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
3: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
4: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
5: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
6: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
7: TFVSGSCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH
8: TFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNH （←Nへの変異）
1161-1200
1: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
2: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
3: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESPID （←Pへの変異）
4: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
5: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
6: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
7: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
8: TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLID
1201-1240
1: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
2: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
3: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
4: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
5: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
6: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
7: LQELGKYEQYIKWPWYIWLGFIAGLIAIIMVTIMLCCMTS
8: LQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTS （←Vへの変異）
1241-1275
1: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
2: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
3: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
4: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
5: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
6: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
7: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
8: CCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
