新型コロナウイルスの起源問題～RaTG13はフェイクか？～2

図2　センザンコウのコロナウイルス、RaTG13、SARS-CoV-2のSタンパク・アミノ酸配列の比較（S1サブユニット）

1: PCoV GX-P1E(2017), 2: PCoV GX-P2V(2018), 3: PCoV GX-P4L(2017),

4: PCoV GX-P5E(2017), 5: PCoV GX-P5L(2017), 6:PCoV MP789(2019),

7: RaTG13(2013), 8: SARS-CoV-2 WIV02(2019)

1-40

1: -MFVFLFVLPLVSSQCVNLTTRTGIQPGYTNSSTRGVYYP

2: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP

3: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP

4: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP

5: -MFVFLFVLPLVSSQCVNLTTRTGIPPGYTNSSTRGVYYP

6: MLFFFFLHFALVNSQCVNLTGRAAIQPSFTNSSQRGVYYP

7: -MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSSTRGVYYP

8: -MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYP

41-80

1: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--NYQGGFKKF

2: DKVFRSSILHLTQDLFLPFFSNVTWFNTIHLNYQGGFKKF

3: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--NYQGGFKKF

4: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--TYQGGSKKF

5: DKVFRSSILHLTQDLFLPFFSNVTWFNTI--NYQGGFKKF

6: DTIFRSNTLVLSQGYFLPFYSNVSWYYALTKTN-SAEKRV

7: DKVFRSSVLHLTQDLFLPFFSNVTWFHAIHVSGTNGIKRF

8: DKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRF

81-120

1: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI

2: DNPVLPXNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI

3: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI

4: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI

5: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDARTQSLLI

6: DNPVLDFKDGIYFAATEKSNIVRGWIFGTTLDNTSQSLLI

7: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLI

8: DNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLI

121-160

1: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV

2: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV

3: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV

4: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV

5: VNNATNVVIKVCEFQFCTDPFLGVYYHNNNKTWVENEFRV

6: VNNATNVIIKVCNFQFCYDPYLSGYYH-NNKTWSTREFAV

7: VNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRV

8: VNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRV

161-200

1: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG

2: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG

3: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG

4: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG

5: YSSANNCTFEYISQPFLMDLEGKQGNFKNLREFVFKNVDG

6: YSSYANCTFEYVSKSFMLDIAGKSGLFDTLREFVFRNVDG

7: YSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDG

8: YSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDG

201-240

1: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ

2: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ

3: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ

4: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ

5: YFKIYSKHTPIDLVRDLPRGFAALEPLVDLPIGINITRFQ

6: YFKIYSKYTPVNVNSNLPIGFSALEPLVEIPAGINITKFR

7: YFKIYSKHTPINLVRDLPPGFSALEPLVDLPIGINITRFQ

8: YFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQ

241-280

1: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY

2: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY

3: TLLALHRSYLTPGNLESGWTTGAAAYYVGYLQQRTFLLSY

4: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY

5: TLLALHRSYLTPGKLESGWTTGAAAYYVGYLQQRTFLLSY

6: TLLTIHRGDPMPN---NGWTVFSAAYYVGYLAPRTFMLNY

7: TLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKY

8: TLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKY

281-320

1: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR

2: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR

3: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR

4: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR

5: NQNGTITDAVDCSLDPLSETKCTLKSLTVEKGIYQTSNFR

6: NENGTITDAVDCALDPLSEAKCTLKSLTVEKGIYQTSNFR

7: NENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFR

8: NENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFR

321-360

1: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS

2: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS

3: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS

4: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS

5: VQPTISIVRFPNITNLCPFGEVFNASKFASVYAWNRKRIS

6: VQPTESIVRFPNITNLCPFGEVFNATTFASVYAWNRKRIS

7: VQPTDSIVRFPNITNLCPFGEVFNATTFASVYAWNRKRIS

8: VQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRIS

361-400

1: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS

2: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS

3: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS

4: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS

5: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS

6: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS

7: NCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADS

8: NCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADS

401-440

1: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV

2: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV

3: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV

4: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV

5: FVVKGDEVRQIAPGQTGVIADYNYKLPDDFTGCVIAWNSV

6: FVVRGDEVRQIAPGQTGRIADYNYKLPDDFTGCVIAWNSN

7: FVITGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSK

8: FVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSN

441-480

1: KQDALTGGNY--LYRLFRKSKLKPFERDISTEIYQAGSTP

2: KQDALTGGNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP

3: KQDALTGGNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP

4: KQDALTGGNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP

5: KQDALTGDNYGYLYRLFRKSKLKPFERDISTEIYQAGSTP

6: NLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTP

7: HIDAKEGGNFNYLYRLFRKANLKPFERDISTEIYQAGSKP

8: NLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTP

481-520

1: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN

2: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSXELLN

3: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN

4: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN

5: CNGQVGLNCYYPLERYGFHPTTGVNYQPFRVVVLSFELLN

6: CNGVEGFNCYFPLQSYGFHPTNGVGYQPYRVVVLSFELLK

7: CNGQTGLNCYYPLYRYGFYPTDGVGHQPYRVVVLSFELLN

8: CNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLH

521-560

1: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF

2: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF

3: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF

4: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF

5: GPATVCGPKLSTTLVKDKCVNFNFNGLTGTGVLTTSKKQF

6: APATVCGPKQSTNLVKNKCVNFNFNGLTGTGVLTESSKKF

7: APATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKF

8: APATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKF

561-600

1: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT

2: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT

3: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT

4: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT

5: LPFQQFGRDISDTTDAVRDPQTLEILDITPCSFGGVSVIT

6: LPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT

7: LPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT

8: LPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT

601-640

1: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG

2: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG

3: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG

4: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG

5: PGTNTSNQVAVLYQDVNCTEVPMAIHAEQLTPAWRVYSAG

6: PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG

7: PGTNASNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG

8: PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTG

641-680-693

1: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSL----RSVNQRS

2: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSF----RSVNQRS

3: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSL----RSVNQRS

4: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSF----RSVNQRS

5: ANVFQTRAGCLVGAEHVNNSYECDIPVGAGICASYHSMSSF----RSVNQRS

6: SNVFQTRAGCLIGAEHVNNTYECDIPIGAGICASYQTQTNS----RSVSSQA

7: SNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS----RSVASQS

8: SNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQS